Metabolic

Semaglutide

aka GLP-1 analogue

GLP-1 receptor agonist. Long-acting GLP-1 analogue widely studied for appetite, satiety, and metabolic research.

GLP-1 analogue
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Certificate of Analysis · 99.5%Lot SLV-26-0412 · HPLC + ISO 17025
HPLC Purity
99.5%
Lot SLV-26-0412
COA verified
CategoryMetabolic
Plasma t½~7 days
Route (research)Subcutaneous (research)
Storage-20°C lyophilized
About Semaglutide

What is Semaglutide?

Semaglutide is a long-acting GLP-1 receptor agonist research peptide and one of the most extensively studied incretin compounds in modern metabolic literature. As a structural analogue of native GLP-1, Semaglutide is engineered for prolonged plasma half-life and enhanced receptor affinity.

Research applications span appetite regulation, satiety modeling, gastric-emptying kinetics, and post-prandial glucose-handling — making it a foundational reference compound in any GLP-1 research workflow.

How it's studied — mechanism

Semaglutide selectively activates the GLP-1 receptor, producing:

  • Sustained satiety signaling via central GLP-1R populations
  • Slowed gastric emptying and modulated post-prandial glucose excursion
  • Insulin-secretion modulation in pancreatic β-cells

The Aib⁸ substitution and C18-diacid acylation extend half-life from minutes (native GLP-1) to roughly a week, making once-weekly research dosing feasible.

Amino acid sequence

Primary structure
GLP-1(7–37) analogue · Aib⁸ · Lys²⁶ acylated (C18 diacid)

Published research

The following primary sources are provided to support qualified-researcher review. Inclusion is for reference only and does not constitute medical advice or therapeutic claim.

Primary literature
Semaglutide STEP-1 review (Wilding et al., 2021)
Research use only Semaglutide is sold strictly for in-vitro research by qualified researchers and is not approved by the FDA for any therapeutic indication. It is not intended to diagnose, treat, cure, or prevent any disease, and is not intended for human or veterinary consumption. All statements on this page describe published research literature and do not constitute medical claims. By purchasing you agree to use Semaglutide only in accordance with applicable federal, state, and local law.
Semaglutide · FAQ

Common research questions.

Is Semaglutide for human consumption? +
No. Semaglutide is sold strictly for in-vitro research use (RUO). It is not approved by the FDA, is not labeled for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm you are a qualified researcher purchasing for laboratory study.
How is Semaglutide synthesized and tested? +
Semaglutide is synthesized at our cGMP-certified partner facility in Texas, USA. Every batch is tested in-house by HPLC and again by an independent ISO 17025 laboratory for identity, purity, water content, and endotoxin. Current lot SLV-26-0412 measured 99.5% purity.
What is the storage protocol? +
Vials of lyophilized Semaglutide should be stored at -20°C lyophilized. After reconstitution with bacteriostatic water for research, refrigerate at 2–8°C and use within the time window specified in our Reconstitution 101 reference.
Where can I find dosing information? +
Solvé maintains a dosing-reference library for qualified researchers. Sign in to your account and confirm researcher attestation to access dose ranges, half-life data, and protocol notes for Semaglutide. All published values reflect peer-reviewed literature, not medical advice.
Does my order include a Certificate of Analysis? +
Yes. The COA for the lot you receive is posted on this product page before you check out, included in your order receipt, and stored in your member dashboard for the lifetime of your account.
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Semaglutide 5 mg · $55
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