Metabolic

Tirzepatide

aka LY3298176

Dual-agonist (GLP-1 / GIP). Dual-receptor research peptide investigated for appetite, glycemic, and metabolic-pathway studies.

Dual-agonistGLP-1GIP
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Certificate of Analysis · 99.3%Lot SLV-26-0419 · HPLC + ISO 17025
HPLC Purity
99.3%
Lot SLV-26-0419
COA verified
CategoryMetabolic
Plasma t½~5 days
Route (research)Subcutaneous (research)
Storage-20°C lyophilized
About Tirzepatide

What is Tirzepatide?

Tirzepatide (LY3298176) is a dual-agonist research peptide targeting both the GLP-1 and GIP receptors. The dual-receptor mechanism is studied for its compounding effects on appetite signaling, gastric emptying, and post-prandial glucose regulation — and has driven significant body-weight reductions in published clinical-research settings.

Tirzepatide remains one of the most heavily-studied incretin-class research compounds and forms a reference point for newer multi-agonist peptides such as Retatrutide.

How it's studied — mechanism

Tirzepatide engages two complementary incretin receptors:

  • GLP-1 receptor — satiety, delayed gastric emptying, modulated insulin secretion
  • GIP receptor — incretin amplification, lipid-utilization pathways

The combined profile is studied for its capacity to amplify the metabolic effects of GLP-1 mono-agonism while reducing the GI-side-effect profile typically seen with high-dose GLP-1 alone.

Amino acid sequence

Primary structure
33-aa modified peptide (His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-…)

Published research

The following primary sources are provided to support qualified-researcher review. Inclusion is for reference only and does not constitute medical advice or therapeutic claim.

Primary literature
Tirzepatide SURMOUNT-1 trial · NCT01573286
Research use only Tirzepatide is sold strictly for in-vitro research by qualified researchers and is not approved by the FDA for any therapeutic indication. It is not intended to diagnose, treat, cure, or prevent any disease, and is not intended for human or veterinary consumption. All statements on this page describe published research literature and do not constitute medical claims. By purchasing you agree to use Tirzepatide only in accordance with applicable federal, state, and local law.
Tirzepatide · FAQ

Common research questions.

Is Tirzepatide for human consumption? +
No. Tirzepatide is sold strictly for in-vitro research use (RUO). It is not approved by the FDA, is not labeled for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm you are a qualified researcher purchasing for laboratory study.
How is Tirzepatide synthesized and tested? +
Tirzepatide is synthesized at our cGMP-certified partner facility in Texas, USA. Every batch is tested in-house by HPLC and again by an independent ISO 17025 laboratory for identity, purity, water content, and endotoxin. Current lot SLV-26-0419 measured 99.3% purity.
What is the storage protocol? +
Vials of lyophilized Tirzepatide should be stored at -20°C lyophilized. After reconstitution with bacteriostatic water for research, refrigerate at 2–8°C and use within the time window specified in our Reconstitution 101 reference.
Where can I find dosing information? +
Solvé maintains a dosing-reference library for qualified researchers. Sign in to your account and confirm researcher attestation to access dose ranges, half-life data, and protocol notes for Tirzepatide. All published values reflect peer-reviewed literature, not medical advice.
Does my order include a Certificate of Analysis? +
Yes. The COA for the lot you receive is posted on this product page before you check out, included in your order receipt, and stored in your member dashboard for the lifetime of your account.
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Tirzepatide 15 mg · $135
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