About MOTS-c
What is MOTS-c?
MOTS-c is a small mitochondrially-encoded peptide derived from an open reading frame within the 12S rRNA gene. Unlike most peptides, it is translated from mitochondrial DNA — making it one of a small class of "mitochondrial-derived peptides" (MDPs) currently under longevity-research investigation.
Preclinical work has linked MOTS-c to AMPK activation, metabolic resilience, and exercise-mimetic signaling.
How it's studied — mechanism
MOTS-c is reported to translocate from mitochondria to the nucleus under metabolic stress and to:
- Activate the AMPK energy-sensing pathway
- Modulate glucose-handling and insulin-sensitivity markers in pre-clinical models
- Influence stress-response gene programs (NRF2, antioxidant response)
Amino acid sequence
Primary structure
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Gln-Glu-Lys-Phe-Ser-Arg-Tyr (16 a.a.)Published research
The following primary sources are provided to support qualified-researcher review. Inclusion is for reference only and does not constitute medical advice or therapeutic claim.
Primary literature
Research use only
MOTS-c is sold strictly for in-vitro research by qualified researchers and is not approved by the FDA for any therapeutic indication. It is not intended to diagnose, treat, cure, or prevent any disease, and is not intended for human or veterinary consumption. All statements on this page describe published research literature and do not constitute medical claims. By purchasing you agree to use MOTS-c only in accordance with applicable federal, state, and local law.