Longevity · Energy

NAD+ Buffered

aka Nicotinamide adenine dinucleotide (ox.)

pH-buffered NAD+ coenzyme. pH-buffered redox cofactor investigated for mitochondrial-energy and sirtuin-pathway research.

Coenzyme · not a peptidepH-buffered
Choose size
$80MEMBER
$100 retail
save $20
Add to cart — $80 Join & save
Free shippingmembers · all orders
Ships same daybefore 2pm ET
30-day MBGrisk-free
cGMP USATexas facility
Certificate of Analysis · 99.1%Lot SLV-26-0408 · HPLC + ISO 17025
HPLC Purity
99.1%
Lot SLV-26-0408
COA verified
CategoryLongevity · Energy
Plasma t½Variable (research)
Route (research)Subcutaneous · IM (research)
Storage-20°C lyophilized
About NAD+ Buffered

What is NAD+ Buffered?

NAD+ Buffered is a pH-stabilized formulation of nicotinamide adenine dinucleotide — a central redox coenzyme involved in nearly every catabolic pathway in human metabolism. Solvé's buffered form mitigates the well-known injection-site discomfort of acidic NAD+ preparations in research workflows.

NAD+ is studied for its role in mitochondrial-electron-transport function, sirtuin signaling, and the broader longevity literature.

Note — NAD+ is a coenzyme, not a peptide. It is included in our catalog because of its frequency in peptide-research workflows.

How it's studied — mechanism

NAD+ functions as the universal electron acceptor in mitochondrial energy metabolism. It is also the obligate substrate for:

  • Sirtuins (SIRT1-7) — protein-deacetylase signaling, longevity-associated pathways
  • PARPs — DNA-damage repair
  • CD38 / CD157 — extracellular NAD+ catabolism

NAD+ tissue levels decline with age, motivating its inclusion in longevity-research stacks.

Amino acid sequence

Primary structure
Not a peptide — coenzyme (nicotinamide adenine dinucleotide)

Published research

The following primary sources are provided to support qualified-researcher review. Inclusion is for reference only and does not constitute medical advice or therapeutic claim.

Primary literature
NAD+ longevity-pathway review (Covarrubias et al., 2021)
Research use only NAD+ Buffered is sold strictly for in-vitro research by qualified researchers and is not approved by the FDA for any therapeutic indication. It is not intended to diagnose, treat, cure, or prevent any disease, and is not intended for human or veterinary consumption. All statements on this page describe published research literature and do not constitute medical claims. By purchasing you agree to use NAD+ Buffered only in accordance with applicable federal, state, and local law.
NAD+ Buffered · FAQ

Common research questions.

Is NAD+ Buffered for human consumption? +
No. NAD+ Buffered is sold strictly for in-vitro research use (RUO). It is not approved by the FDA, is not labeled for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm you are a qualified researcher purchasing for laboratory study.
How is NAD+ Buffered synthesized and tested? +
NAD+ Buffered is synthesized at our cGMP-certified partner facility in Texas, USA. Every batch is tested in-house by HPLC and again by an independent ISO 17025 laboratory for identity, purity, water content, and endotoxin. Current lot SLV-26-0408 measured 99.1% purity.
What is the storage protocol? +
Vials of lyophilized NAD+ Buffered should be stored at -20°C lyophilized. After reconstitution with bacteriostatic water for research, refrigerate at 2–8°C and use within the time window specified in our Reconstitution 101 reference.
Where can I find dosing information? +
Solvé maintains a dosing-reference library for qualified researchers. Sign in to your account and confirm researcher attestation to access dose ranges, half-life data, and protocol notes for NAD+ Buffered. All published values reflect peer-reviewed literature, not medical advice.
Does my order include a Certificate of Analysis? +
Yes. The COA for the lot you receive is posted on this product page before you check out, included in your order receipt, and stored in your member dashboard for the lifetime of your account.
Researchers also viewed

Related compounds.

99.0%
MOTS-c
Mitochondrially-encoded peptide · 16 a.a.

Mitochondria-encoded peptide investigated for AMPK signaling and metabolic-resilience research.

$50memberretail $60
View
99.3%
Tesamorelin
Stabilized GHRH (1-44) analogue

Stabilized GHRH analogue studied for somatotropic-axis and visceral-adiposity research.

$90memberretail $115
View
99.4%
Sermorelin
GHRH (1-29) amide

Truncated GHRH analogue studied for pulsatile GH release and recovery-pathway research.

$55memberretail $70
View
Become a member

Members save on every order.

Members get up to 20% off every vial, free BAC water, free shipping, and the entire research toolkit — calculator, tracker, protocols, community.

Join Solvé — from $39/mo Browse the catalog
NAD+ Buffered 500 mg · $80
Add to cart