Growth Hormone

Sermorelin

aka GRF(1-29) amide

GHRH (1-29) amide. Truncated GHRH analogue studied for pulsatile GH release and recovery-pathway research.

GHRH(1-29) amide
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cGMP USATexas facility
Certificate of Analysis · 99.4%Lot SLV-26-0414 · HPLC + ISO 17025
HPLC Purity
99.4%
Lot SLV-26-0414
COA verified
CategoryGrowth Hormone
Plasma t½~10–20 minutes (plasma)
Route (research)Subcutaneous (research)
Storage-20°C lyophilized
About Sermorelin

What is Sermorelin?

Sermorelin is a 29-amino-acid amide corresponding to the active N-terminal fragment of native GHRH. It retains full GHRH-receptor binding activity in a more economical, easier-to-manufacture sequence than the full 44-residue parent peptide.

Sermorelin is widely used as a research benchmark for pulsatile somatotropic-axis stimulation and is frequently studied alongside Tesamorelin and CJC-1295 as part of GHRH-class investigations.

How it's studied — mechanism

Sermorelin binds the GHRH receptor on pituitary somatotrophs, evoking a physiologic pulse of endogenous growth hormone — preserving the body's negative-feedback architecture, unlike exogenous GH administration. Downstream effects mirror native GHRH activity.

Amino acid sequence

Primary structure
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂

Published research

The following primary sources are provided to support qualified-researcher review. Inclusion is for reference only and does not constitute medical advice or therapeutic claim.

Primary literature
Sermorelin overview (Walker, 2006)
Research use only Sermorelin is sold strictly for in-vitro research by qualified researchers and is not approved by the FDA for any therapeutic indication. It is not intended to diagnose, treat, cure, or prevent any disease, and is not intended for human or veterinary consumption. All statements on this page describe published research literature and do not constitute medical claims. By purchasing you agree to use Sermorelin only in accordance with applicable federal, state, and local law.
Sermorelin · FAQ

Common research questions.

Is Sermorelin for human consumption? +
No. Sermorelin is sold strictly for in-vitro research use (RUO). It is not approved by the FDA, is not labeled for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm you are a qualified researcher purchasing for laboratory study.
How is Sermorelin synthesized and tested? +
Sermorelin is synthesized at our cGMP-certified partner facility in Texas, USA. Every batch is tested in-house by HPLC and again by an independent ISO 17025 laboratory for identity, purity, water content, and endotoxin. Current lot SLV-26-0414 measured 99.4% purity.
What is the storage protocol? +
Vials of lyophilized Sermorelin should be stored at -20°C lyophilized. After reconstitution with bacteriostatic water for research, refrigerate at 2–8°C and use within the time window specified in our Reconstitution 101 reference.
Where can I find dosing information? +
Solvé maintains a dosing-reference library for qualified researchers. Sign in to your account and confirm researcher attestation to access dose ranges, half-life data, and protocol notes for Sermorelin. All published values reflect peer-reviewed literature, not medical advice.
Does my order include a Certificate of Analysis? +
Yes. The COA for the lot you receive is posted on this product page before you check out, included in your order receipt, and stored in your member dashboard for the lifetime of your account.
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