About MT-II
What is MT-II?
Melanotan II (MT-II) is a cyclic synthetic analogue of α-MSH (alpha-melanocyte-stimulating hormone). The lactam bridge between Asp and Lys constrains the molecule into a bioactive conformation, increasing potency and proteolytic stability relative to linear α-MSH.
MT-II is studied across the melanocortin-receptor family — pigmentation pathways via MC1R, and central libido/arousal pathways via MC3R/MC4R.
How it's studied — mechanism
MT-II is a non-selective agonist of the melanocortin-receptor family:
- MC1R — eumelanin synthesis in epidermal melanocytes
- MC3R / MC4R — central appetite and sexual-behavior pathways
- MC5R — exocrine signaling
Amino acid sequence
Primary structure
Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH₂ (cyclic lactam Asp↔Lys)Published research
The following primary sources are provided to support qualified-researcher review. Inclusion is for reference only and does not constitute medical advice or therapeutic claim.
Primary literature
Research use only
MT-II is sold strictly for in-vitro research by qualified researchers and is not approved by the FDA for any therapeutic indication. It is not intended to diagnose, treat, cure, or prevent any disease, and is not intended for human or veterinary consumption. All statements on this page describe published research literature and do not constitute medical claims. By purchasing you agree to use MT-II only in accordance with applicable federal, state, and local law.