About GHK-Cu
What is GHK-Cu?
GHK-Cu (Copper tripeptide-1) is a naturally-occurring tripeptide that binds Cu²⁺ with high affinity. Plasma concentrations of GHK decline measurably with age, and the compound has been studied extensively for its role in extracellular-matrix remodeling, wound-pathway research, and dermal-collagen signaling.
Of all the peptides in this catalog, GHK-Cu has one of the longest research literatures, dating back to the 1970s.
How it's studied — mechanism
The GHK-Cu complex is reported to influence:
- Collagen synthesis — type I and type III collagen up-regulation in fibroblasts
- Extracellular-matrix remodeling — modulation of MMP / TIMP balance
- Antioxidant pathways — copper-dependent SOD activity
- Hair-follicle research — effects on dermal-papilla cell proliferation
Amino acid sequence
Primary structure
Gly-His-Lys (copper complex · Cu²⁺)Published research
The following primary sources are provided to support qualified-researcher review. Inclusion is for reference only and does not constitute medical advice or therapeutic claim.
Primary literature
Research use only
GHK-Cu is sold strictly for in-vitro research by qualified researchers and is not approved by the FDA for any therapeutic indication. It is not intended to diagnose, treat, cure, or prevent any disease, and is not intended for human or veterinary consumption. All statements on this page describe published research literature and do not constitute medical claims. By purchasing you agree to use GHK-Cu only in accordance with applicable federal, state, and local law.